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Article

Preferential killing of p53-deficient cancer cells by reversine

31 May 2012

Abstract excerpt

Reversine is a small synthetic molecule that inhibits multiple mitotic kinases, including MPS1 as well as Aurora kinase A and B (AURKA and AURKB). Here, we investigated the effects of reversine on p53-deficient vs p53-proficient cancer cells. We found that low doses (~0.5 µM) of reversine, which selectively inhibit MPS1 and hence impair the spindle assembly checkpoint, kill human TP53 (-/-) colon carcinoma cells...

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PMID: 22592527
DOI: 10.4161/cc.20621

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