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Synthetic Lethality Targeting Polθ

20 Jun 2022

Abstract excerpt

Research studies regarding synthetic lethality (SL) in human cells are primarily motivated by the potential of this phenomenon to be an effective, but at the same time, safe to the patient's anti-cancer chemotherapy. Among the factors that are targets for the induction of the synthetic lethality effect, those involved in DNA repair seem to be the most relevant. Specifically, when mutation in one of the canonical...

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PMID: 35741863
DOI: 10.3390/genes13061101

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