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Expected Plazomicin Susceptibility in India Based on the Prevailing Aminoglycoside Resistance Mechanisms in Gram-Negative Organisms Derived from Whole-Genome Sequencing

1 Jul 2020

Abstract excerpt

Background: Aminoglycoside resistance is a growing challenge, and it is commonly mediated by the aminoglycoside-modifying enzymes (AMEs), followed by 16S rRNA methyl transferase. Plazomicin, a novel aminoglycoside agent approved by the Food and Drug Administration for complicated urinary tract infections is proven to overcome resistance mediated by AMEs but not due to 16S rRNA methyl transferase (16SRMTases). We...

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Antibiotic Resistance in Bacteria
Genomics and Phylogenetic Studies
Microbial Natural Products and Biosynthesis

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33154241
DOI: 10.4103/ijmm.ijmm_20_384

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