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Aerobic glycolysis supports hepatitis B virus biosynthesis through interaction between viral surface antigen and pyruvate kinase isoform M2

2020-08-10

Abstract excerpt

As an intracellular pathogen, the reproduction of hepatitis B virus (HBV) depends on the occupancy of host metabolism machinery. Here we test a hypothesis if HBV may govern intracellular biosynthesis to achieve a productive reproduction. To test this hypothesis, we set up an affinity purification screen for host factors that interact with viral large surface antigen (LHBS). This identified pyruvate kinase isoform...

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Identifiers and source

Literature Corpus work
4eb2e7f5-2f9a-522b-9e30-8656506b9b42
DOI
10.1101/2020.08.10.244038
Open publication

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Aerobic glycolysis supports hepatitis B virus biosynthesis through interaction between viral surface antigen and pyruvate kinase isoform M2DOI 10.1101/2020.08.10.244038
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