Article

AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in Castrate-Resistant Prostate Cancer

2021-06-03

Abstract excerpt

<h4>Summary</h4> Expression of the AR splice variant, AR-V7, in prostate cancer is correlated with poor patient survival and resistance to AR targeted therapies and taxanes. Currently, there is no specific inhibitor of AR-V7, while the molecular mechanisms regulating its biological function are not well elucidated. Here we report that AR-V7 has unique biological features that functionally differentiate it from ca...

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Literature Corpus work: 4eb2c96f-672b-5609-b61c-4d4ff367c22b
DOI: 10.1101/2021.06.03.446940

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