Investigating the impact of obesity as an immunological instigator on young-onset arthritis using perturbation-based simulation

Abstract excerpt

<h4>Purpose</h4> Young-onset inflammatory arthritis (YOA; disease onset at age <25) incidence has risen since 1990, coinciding with the childhood obesity epidemic. Traditional epidemiology cannot easily quantify obesity’s contribution because early-life exposures can precede clinical onset by years and may be poorly measured at diagnosis. We developed a perturbation-based simulation to estimate young-age inflamma...

Topics

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• Arthritis, Rheumatoid
• Body Mass Index
• Body Size
• Causality
• Mendelian Randomization Analysis
• Obesity
• Odds Ratio
• Waist-Hip Ratio

Identifiers and source

Literature Corpus work

4e647d5c-9f2c-5f71-a59d-cd15c005c948

DOI

10.64898/2026.01.29.702692