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Associations of accelerated biological aging and metabolic heterogeneity of obesity with rheumatoid arthritis: a prospective cohort study.

Clinical rheumatology - 1 Dec 2024

Zhao Chan-Na, Jiang Ling-Qiong, Musonye Harry Asena, Meng Shi-Yin, He Yi-Sheng, Wang Peng, Ni Jing, Pan Hai-Feng

Abstract excerpt

OBJECTIVE: To evaluate the associations between biological aging, metabolic heterogeneity of obesity, and rheumatoid arthritis (RA). METHODS: This prospective cohort study analyzed 268,184 individuals from the UK Biobank. Biological age was estimated using phenotypic age (PhenoAge), Klemera-Doubal methods (KDM-BA), and telomere length. We calculated KDM-BA acceleration and PhenoAge acceleration after subtracting...

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PMID: 39367918
DOI: 10.1007/s10067-024-07167-0

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