Article

The proteomic landscape of proteotoxic stress in a fibrogenic liver disease

2024-11-03

Abstract excerpt

Protein misfolding diseases, including alpha-1 antitrypsin deficiency (AATD), pose significant health challenges, with their cellular progression still poorly understood 1–3 . We utilize spatial proteomics by mass spectrometry and machine learning to map AATD in human liver tissue. Combining Deep Visual Proteomics (DVP) with single-cell analysis 4,5 , we probe intact patient biopsies to resolve molecular events...

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Literature Corpus work: 4e53679d-50f2-5091-a234-256686930633
DOI: 10.1101/2024.11.01.621457

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