Article

Single-Cell Resolution of Cellular Damage Illuminates Disease Progression

2025-02-26

Abstract excerpt

<h4>Summary</h4> Degenerative diseases feature progressive accumulation of cellular damage, leading to impaired organ function. Capturing such gradual decline of individual cells in vivo remains challenging. Here, we present a universal framework for quantifying damage at single-cell resolution, to uncover molecular trajectories of degeneration. This method enables the detection of progressive damage within cell...

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Literature Corpus work: 243aef34-d63f-55bb-8ec9-89c7f160bda8
DOI: 10.1101/2025.02.20.639269

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