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Article

Mechanism of direct bicarbonate transport by the CFTR anion channel.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Mar 2009

Tang Lin, Fatehi Mohammad, Linsdell Paul

Abstract excerpt

BACKGROUND: CFTR contributes to HCO(3)(-) transport in epithelial cells both directly (by HCO(3)(-) permeation through the channel) and indirectly (by regulating Cl(-)/HCO(3)(-) exchange proteins). While loss of HCO(3)(-) transport is highly relevant to cystic fibrosis, the relative importance of direct and indirect HCO(3)(-) transport it is currently unknown. METHODS: Patch clamp recordings from membrane patches...

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Source

Identifiers

PMID: 19019741
DOI: 10.1016/j.jcf.2008.10.004

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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