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Article

Mouse Model of <i>SCN5A</i> -Linked Hereditary Lenegre’s Disease

5 Apr 2005

Abstract excerpt

BACKGROUND: We have previously linked hereditary progressive cardiac conduction defect (hereditary Lenègre's disease) to a loss-of-function mutation in the gene encoding the main cardiac Na+ channel, SCN5A. In the present study, we investigated heterozygous Scn5a-knockout mice (Scn5a+/- mice) as a model for hereditary Lenègre's disease. METHODS AND RESULTS: In Scn5a+/- mice, surface ECG recordings showed...

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PMID: 15809371
DOI: 10.1161/01.cir.0000160853.19867.61

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