Back to search

Article

The Effect of Targeted Vaccination Against Mycobacterium Avium ssp. Paratuberculosis (MAP) in a Multiple Sclerosis Mouse Model: Implications for Causation

2017-10-12

Abstract excerpt

Epidemiologic evidence relating to the causation of Multiple Sclerosis, based upon twin concordance studies, implicates both genetic and environmental contributions. The HLA-DRB1/ HLA-A haplotype confers a 23 fold increase in MS prevalence above its baseline of 1 per 1,000 persons. Epigenetic factors, such as an aberrant response to Epstein Barr Virus (EBV) and Vitamin D deficiency can increase that risk 36 and 2...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4dffa7d6-cb81-54ab-b9a4-1c2edeee05b0
DOI
10.1101/202275
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The Effect of Targeted Vaccination Against Mycobacterium Avium ssp. Paratuberculosis (MAP) in a Multiple Sclerosis Mouse Model: Implications for CausationDOI 10.1101/202275
Mapping of CD8 T-cell recognition to latent EBV infection and neuroantigens reveals HLA-specific depletion of T-cell responses in multiple sclerosisSemantic proximity
Genetic analysis of the influence of neuroantigen-complete Freund's adjuvant emulsion structures on the sexual dimorphism and susceptibility to experimental allergic encephalomyelitis.Semantic proximity
Epstein–Barr virus and Mycobacterium avium subsp. paratuberculosis peptides are cross recognized by anti-myelin basic protein antibodies in multiple sclerosis patientsSemantic proximity
Gender, age, and season at immunization uniquely influence the genetic control of susceptibility to histopathological lesions and clinical signs of experimental allergic encephalomyelitis: implications for the genetics of multiple sclerosis.Semantic proximity
Modeling subacute sclerosing panencephalitis in a transgenic mouse system: uncoding pathogenesis of disease and illuminating components of immune control.Semantic proximity
Gene-environment interactions between HLA B7/A2, EBV antibodies are associated with MRI injury in multiple sclerosis.Semantic proximity
Multiple sclerosis and myelin basic protein: insights into protein disorder and diseaseSemantic proximity
HLA-DQ polymorphism influences progression of demyelination and neurologic deficits in a viral model of multiple sclerosis.Semantic proximity
Delineating the impact of neuroantigen vs genetic diversity on MP4-induced EAE of C57BL/6 and B6.129 mice.Semantic proximity
Association of Mycobacterium avium subsp. paratuberculosis with Multiple Sclerosis in Sardinian PatientsSemantic proximity
A Lymph Node Targeted Adjuvant and Engineered Subunit Vaccine Promotes Potent Immunity to Epstein-Barr Virus in HLA-expressing MiceSemantic proximity
Comparison of immunoglobulin G heavy-chain sequences in MS and SSPE brains reveals an antigen-driven responseSemantic proximity
Select a neighboring publication to make it the new centre.