Article

Histone H3K4me3 and H3K9me3 are super over-methylated in soft tissue sarcoma compared to normal muscle in patient-derived xenograft (PDX) mouse models: an indicator of cancer methionine addiction

2021-01-05

Abstract excerpt

Methionine addiction is a fundamental and general hallmark of cancer discovered by us almost a half-century ago [Proc Natl Acad Sci U S A 73 (1976) 1523-1527]. Methionine addiction is defined as the requirement, specific for cancer cells of all types, for exogenous methionine despite the normal ability to synthesize methionine from homocysteine. The methionine addiction of cancer is termed the Hoffman-effect, anal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4dfb6c7e-b886-5c54-8892-f0cb2a591be9
DOI: 10.1101/2021.01.01.425040

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Histone H3K4me3 and H3K9me3 are super over-methylated in soft tissue sarcoma compared to normal muscle in patient-derived xenograft (PDX) mouse models: an indicator of cancer methionine addictionDOI 10.1101/2021.01.01.425040Read

Over-methylation of Histone H3 Lysines Is a Common Molecular Change Among the Three Major Types of Soft-tissue Sarcoma in Patient-derived Xenograft (PDX) Mouse ModelsSemantic proximity Read

Extent and Instability of Trimethylation of Histone H3 Lysine Increases With Degree of Malignancy and Methionine AddictionSemantic proximity Read

Epigenetic reprogramming induced by Acetyl-CoA and SAM depletion is an evolutionarily-ancient path to malignant growthSemantic proximity Read

Epigenetic reprogramming induced by key metabolite depletion is an evolutionarily ancient path to tumorigenesis.Semantic proximity Read

Comparative oncology reveals DNMT3B as a molecular vulnerability in soft-tissue sarcomaSemantic proximity Read

Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.Semantic proximity Read

A metabolic crosstalk between liposarcoma and muscle sustains tumor growthSemantic proximity Read

Assessment of patient-derived tumour xenografts (PDXs) as a discovery tool for cancer epigenomicsSemantic proximity Read

Deletion ofMTAPHighly Sensitizes Osteosarcoma Cells to Methionine Restriction With Recombinant MethioninaseSemantic proximity Read

Targeting MCM2 activates cancer-associated fibroblasts-like phenotype and affects chemo-resistance of liposarcoma cells against doxorubicin.Semantic proximity Read

Epigenetics of cancer-associated muscle catabolismSemantic proximity Read

Induction of serine hydroxymethyltransferase 2 promotes tumorigenesis and metastasis in neuroblastomaSemantic proximity Read