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Article

Targeting MCM2 activates cancer-associated fibroblasts-like phenotype and affects chemo-resistance of liposarcoma cells against doxorubicin.

Anti-cancer drugs - 1 Nov 2024

Bai Chujie, Li Shu, Tan Zhichao, Fan Zhengfu

Abstract excerpt

Liposarcoma is one of the most common soft tissue malignancies. We previously discovered upregulation of minichromosome maintenance 2 (MCM2) expression in liposarcoma tissues. Hereon, we attempt to clarify the biological influence and mechanisms of MCM2 in liposarcoma. The mRNA level of MCM2 expression was detected through the use of quantitative real-time PCR. Immunohistochemistry staining and western blot were...

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Identifiers

PMID: 39109389
DOI: 10.1097/CAD.0000000000001641

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