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Article

A metabolic crosstalk between liposarcoma and muscle sustains tumor growth

12 Sept 2024

Abstract excerpt

Dedifferentiated and Well-differentiated liposarcoma are characterized by a systematic amplification of the Murine Double Minute 2 (MDM2) oncogene. We demonstrate that p53-independent metabolic functions of chromatin-bound MDM2 are exacerbated in liposarcoma and mediate an addiction to serine metabolism to sustain tumor growth. However, the origin of exogenous serine remains unclear. Here, we show that elevated...

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PMID: 39266552
DOI: 10.1038/s41467-024-51827-3

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