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GPR4 aggravates ferroptosis in nucleus pulposus cells by inhibiting mitophagy via MAPK pathway activation

2025-10-07

Abstract excerpt

<title>Abstract</title> <p>Inflammatory diseases are known to lower the pH of the extracellular microenvironment. However, the role of proton-activated G protein-coupled receptors (GPRs) in the progression of intervertebral disc degeneration (IVDD) remains largely unexplored. In this study, we identified GPR4 as a key regulator of IVDD progression. Our analysis revealed a significant upregulation of GPR4 in degen...

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Literature Corpus work
4df8725e-6f13-5dc4-8e50-51160f61a91d
DOI
10.21203/rs.3.rs-7509828/v1
Open publication

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GPR4 aggravates ferroptosis in nucleus pulposus cells by inhibiting mitophagy via MAPK pathway activationDOI 10.21203/rs.3.rs-7509828/v1
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