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Validation and the role of PDK4 relevant to ferroptosis in degenerative lumbar disc disease

10 Jan 2025

Abstract excerpt

BACKGROUND: Ferroptosis was involved in the pathogenesis of intervertebral disc degeneration (IVDD). However, the exact mechanism of IVDD associated with ferroptosis still required deeper studies. METHOD: The differentially expressed genes (DEGs) in rat lumbar disc tissue between the control and IVDD group treated with IL-1β were detected by RNA sequencing (RNA-seq). Gene Ontology (GO) and Kyoto Encyclopedia of...

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PMID: 39794775
DOI: 10.1186/s13018-024-05293-8

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