Article

Precision combination therapies based on recurrent oncogenic co-alterations

2020-06-04

Abstract excerpt

Cancer cells depend on multiple driver alterations whose oncogenic effects can be suppressed by drug combinations. Discovery of effective combination therapies is challenging due to the complexity of the biomolecular landscape of drug responses. Here, we developed the method REFLECT (REcurrent Features Leveraged for Combination Therapies), which integrates machine learning and cancer informatics algorithms. The me...

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Literature Corpus work: 4deaf10c-4b41-5bb5-bd9f-003c155a3092
DOI: 10.1101/2020.06.03.132514

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