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Overcoming therapeutic resistance in pancreatic cancer: Emerging opportunities by targeting BRCAs and p53

16 May 2023

Abstract excerpt

Pancreatic cancer (PC) is characterized by (epi)genetic and microenvironmental alterations that negatively impact the treatment outcomes. New targeted therapies have been pursued to counteract the therapeutic resistance in PC. Aiming to seek for new therapeutic options for PC, several attempts have been undertaken to exploit BRCA1/2 and TP53 deficiencies as promising actionable targets. The elucidation of the...

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PMID: 37201730
DOI: 10.1016/j.bbcan.2023.188914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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