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RNA expression data suggest ALDH2 inhibition as a concept for killing acute myeloid leukemia cells that are resistant to ALDH1 inhibitors: the example of NPM1 mutant AML

2024-11-10

Abstract excerpt

In this data paper we present a study of RNA expression in association with the disease course of acute myeloid leukemia (AML). We have previously identified aldehyde dehydrogenase genes ALDH1A1 and ALDH2 as prospective actionable targets in AML. ALDH1A1 is expected to have key functions in leukemia stem-like cells that are prone to a dormant state in terms of metabolic activity and proliferation. Cells with a hig...

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Literature Corpus work: 4de0be86-7cd8-587e-ab52-126fb208dc9f
DOI: 10.1101/2024.11.09.24317037

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