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Cell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation

8 May 2023

Abstract excerpt

Cell-selective proteomics is a powerful emerging concept to study heterocellular processes in tissues. However, its high potential to identify non-cell-autonomous disease mechanisms and biomarkers has been hindered by low proteome coverage. Here, we address this limitation and devise a comprehensive azidonorleucine labeling, click chemistry enrichment, and mass spectrometry-based proteomics and secretomics...

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PMID: 37156840
DOI: 10.1038/s41467-023-38171-8

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