Article

High prevalence of S. pyogenes Cas9-specific T cell sensitization within the adult human population – A balanced effector/regulatory T cell response

2018-04-04

Abstract excerpt

<h4>Summary Paragraph</h4> The field of gene therapy has been galvanized by the discovery of the highly efficient and adaptable site-specific nuclease system CRISPR/Cas9 from bacteria. 1,2 Immunity against therapeutic gene vectors or gene-modifying cargo nullifies the effect of a possible curative treatment and may pose significant safety issues. 3-5 Immunocompetent mice treated with CRISPR/Cas9-encoding vector...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4da51774-cbe6-5025-9bd7-77182506e9fa
DOI: 10.1101/295139

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High prevalence of S. pyogenes Cas9-specific T cell sensitization within the adult human population – A balanced effector/regulatory T cell responseDOI 10.1101/295139Read

High prevalence of Streptococcus pyogenes Cas9-reactive T cells within the adult human populationSemantic proximity Read

Multifunctional CRISPR/Cas9 with engineered immunosilenced human T cell epitopesSemantic proximity Read

Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopesSemantic proximity Read

Identification of Pre-Existing Adaptive Immunity to Cas9 Proteins in HumansSemantic proximity Read

Cas9-directed immune tolerance in humans—a model to evaluate regulatory T cells in gene therapy?Semantic proximity Read

Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humansSemantic proximity Read

Immunity to CRISPR Cas9 and Cas12a therapeuticsSemantic proximity Read

Identification of preexisting adaptive immunity to Cas9 proteins in humansSemantic proximity Read

Investigation of Cas9 antibodies in the human eyeSemantic proximity Read

Detection of Pre-Existing Immunity to Bacterial Cas9 Proteins in People with Cystic FibrosisSemantic proximity Read

Immunity to Cas9 as an Obstacle to Persistent Genome EditingSemantic proximity Read

A dynamic subpopulation of CRISPR-Cas overexpressers allows Streptococcus pyogenes to rapidly respond to phage.Semantic proximity Read