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Investigation of Cas9 antibodies in the human eye

25 Feb 2022

Abstract excerpt

Preexisting immunity against Cas9 proteins in humans represents a safety risk for CRISPR-Cas9 technologies. However, it is unclear to what extent preexisting Cas9 immunity is relevant to the eye as it is targeted for early in vivo CRISPR-Cas9 clinical trials. While the eye lacks T-cells, it contains antibodies, cytokines, and resident immune cells. Although precise mechanisms are unclear, intraocular inflammation...

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PMID: 35217666
DOI: 10.1038/s41467-022-28674-1

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