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Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes

23 Apr 2019

Abstract excerpt

The CRISPR-Cas9 system has raised hopes for developing personalized gene therapies for complex diseases. Its application for genetic and epigenetic therapies in humans raises concerns over immunogenicity of the bacterially derived Cas9 protein. Here we detect antibodies to Streptococcus pyogenes Cas9 (SpCas9) in at least 5% of 143 healthy individuals. We also report pre-existing human CD8+T cell immunity in the...

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PMID: 31015529
DOI: 10.1038/s41467-019-09693-x

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