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Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans

6 Jun 2022

Abstract excerpt

RNA-guided RNA-targeting nucleases, such as CRISPR-Cas13 proteins, have therapeutic potential for gene editing. Among Cas13d enzymes, Cas13d from the bacteria Ruminococcus flavefaciens (RfxCas13d) is of particular interest owing to its small size and high specificity. However, the existence of pre-existing immunity against RfxCas13d is unclear. In this study, we evaluated antibody and T cell responses to...

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PMID: 35668177
DOI: 10.1038/s41591-022-01848-6

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