Article

Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

2023-12-18

Abstract excerpt

The enteric nervous system (ENS), a collection of neural cells contained in the wall of the gut, is of fundamental importance to gastrointestinal and systemic health. According to the prevailing paradigm, the ENS arises from progenitor cells migrating from the neural crest and remains largely unchanged thereafter. Here, we show that the lineage composition of maturing ENS changes with time, with a decline in the c...

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Literature Corpus work: 4a5965c8-81ee-5860-bd86-4f3523344051
DOI: 10.7554/elife.88051.2

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