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ZNF276 promotes the malignant phenotype of breast carcinoma by activating the CYP1B1-mediated Wnt/β-catenin pathway.

Cell death & disease - 10 Sept 2022

Lei Ting, Zhang Wenwu, He Yongyin, Wei Shi, Song Xiaoyu, Zhu Yi, Luo Guoqing, Kuang Zhenzhan, Li Guanjie, Zhou Quan, Sun Zhaohui, Xiao Bin, Li Linhai

Abstract excerpt

Zinc finger proteins (ZNFs) have been demonstrated to participate extensively in breast cancer progression by functioning as transcription factors, but there are still a variety of ZNFs whose biological mechanisms remain unknown. Here, we show that zinc finger protein 276 (ZNF276) is highly expressed in breast cancer tissues and cell lines. Higher level of ZNF276 correlated with poor prognosis. Gain-of and...

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Identifiers

PMID: 36085146
DOI: 10.1038/s41419-022-05223-8
PMCID: PMC9463175

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