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Nasal anti-CD3 mAb (Foralumab) dampens CD3+ T effector function and decreases NKG7 in COVID-19 through a mechanism involving GIMAP-7 and TGFb1

2022-10-13

Abstract excerpt

<title>Abstract</title> <p>T cells are present in early stages of the SARS-CoV-2 infection and play a major role in disease outcome and long-lasting immunity. Nasal administration of a fully humanized anti-CD3 monoclonal antibody (Foralumab) reduced lung inflammation as well as serum IL-6 and C-reactive protein in moderate cases of COVID-19. Using RNA-sequencing and serum proteomics, we investigated the immune ch...

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Literature Corpus work
4d6849b8-4c56-508b-973e-2e027e7ff1bd
DOI
10.21203/rs.3.rs-2061549/v1
Open publication

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Nasal anti-CD3 mAb (Foralumab) dampens CD3+ T effector function and decreases NKG7 in COVID-19 through a mechanism involving GIMAP-7 and TGFb1DOI 10.21203/rs.3.rs-2061549/v1
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