Article

Single-cell multi-omics show disruption of blood and airway T-cells in pulmonary long COVID

2025-09-19

Abstract excerpt

<h4>Background</h4> Approximately 10% of individuals who recover from COVID-19 experience residual respiratory symptoms impacting their quality of life, but the mechanisms behind pulmonary long COVID (PLC) are largely unknown. <h4>Objectives</h4> We characterized airway and circulating immune cells in patients with and without PLC. <h4>Methods</h4> Participants were recruited and allocated into two groups: 1) P...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 430af946-11ff-56b8-a561-123865c2ed1c
DOI: 10.1101/2025.09.18.25336101

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell multi-omics show disruption of blood and airway T-cells in pulmonary long COVIDDOI 10.1101/2025.09.18.25336101Read

Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolutionSemantic proximity Read

The landscape of lung bronchoalveolar immune cells in COVID-19 revealed by single-cell RNA sequencingSemantic proximity Read

Comparative transcriptomic analyses of peripheral blood mononuclear cells of patients with non-pneumonia and severe pneumonia at 1 year-Long-COVID-19Semantic proximity Read

Identification of soluble biomarkers that associate with distinct manifestations of long COVIDSemantic proximity Read

Sex differences and immune correlates of Long COVID development, persistence, and resolutionSemantic proximity Read

Analysis of respiratory and systemic immune responses in COVID-19 reveals mechanisms of disease pathogenesisSemantic proximity Read

Single cell sequencing reveals cellular landscape alterations in the airway mucosa of patients with pulmonary long COVIDSemantic proximity Read

Single‐cell RNA sequencing reveals characteristics of myeloid cells in post-acute sequelae of SARS-CoV-2 patients with persistent respiratory symptomsSemantic proximity Read

Single cell transcriptomic re-analysis of immune cells in bronchoalveolar lavage fluids reveals the correlation of B cell characteristics and disease severity of patients with SARS-CoV-2 infectionSemantic proximity Read

Single-cell RNA sequencing reveals characteristics of myeloid cells in pulmonary post-acute sequelae of SARS-CoV-2Semantic proximity Read

Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individualsSemantic proximity Read

Characterisation of the blood RNA host response underpinning severity in COVID-19 patientsSemantic proximity Read