Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19

21 Jan 2022

Abstract excerpt

Abstract Dysregulated immune responses against the SARS-CoV-2 virus are instrumental in severe COVID-19. However, the immune signatures associated with immunopathology are poorly understood. Here we use multi-omics single-cell analysis to probe the dynamic immune responses in hospitalized patients with stable or progressive course of COVID-19, explore V(D)J repertoires, and assess the cellular effects of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19 Clinical Research Studies
Share to SARS-CoV-2 and COVID-19 Research
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35064122
DOI: 10.1038/s41467-021-27716-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19PMID 35064122Read ↗

Single-Cell Omics Reveals Dyssynchrony of the Innate and Adaptive Immune System in Progressive COVID-19Semantic proximity Read ↗

A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunitySemantic proximity Read ↗

Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individualsSemantic proximity Read ↗

Single-cell multi-omics analysis of the immune response in COVID-19Semantic proximity Read ↗

Identification of Distinct Immune Cells Associated with Various Clinical Presentations of COVID-19Semantic proximity Read ↗

Immune Cell Profiling of COVID-19 Patients in the Recovery Stage by Single-Cell SequencingSemantic proximity Read ↗

Cell specific peripheral immune responses predict survival in critical COVID-19 patientsSemantic proximity Read ↗

Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19Semantic proximity Read ↗

Identification of Distinct Immune Cell Subsets Associated With Asymptomatic Infection, Disease Severity, and Viral Persistence in COVID-19 PatientsSemantic proximity Read ↗

The cellular immune response to COVID-19 deciphered by single cell multi-omics across three UK centresSemantic proximity Read ↗

Cellular heterogeneity in disease severity and clinical outcome: Granular understanding of immune response is key.Semantic proximity Read ↗

Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection TrajectoriesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.