Article

Gliamimic: A Longitudinal, Multimodal in Vitro Platform for Evaluating Glioblastoma Treatment Response and Relapse in Patient-derived Organoids or Spheroids

2025-12-01

Abstract excerpt

<title>Abstract</title> <p> Despite decades of research, glioblastoma (GBM) remains highly treatment-resistant, underscoring the need for human-relevant <italic>in vitro</italic> models to better predict therapy response and recurrence. We developed GliaMimic, an advanced platform that exposes GBM patient-derived organoids (PDOs) or tumor cell line-based spheroids to a combined TMZ and radiotherapy regimen ada...

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Literature Corpus work: 35c8d53f-81c3-546a-851d-1ccac5869dd8
DOI: 10.21203/rs.3.rs-8032464/v1

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