Article

DNA methylation classification in diffuse glioma shows little spatial heterogeneity after adjusting for tumor purity

2020-03-29

Abstract excerpt

Intratumoral heterogeneity is a hallmark of diffuse gliomas. We used neuronavigation to acquire 133 image-guided and spatially-separated stereotactic biopsy samples from 16 adult patients with a diffuse glioma, which we characterized using DNA methylation arrays. Samples were obtained from regions with and without imaging abnormalities. Methylation profiles were analyzed to devise a three-dimensional reconstructio...

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Literature Corpus work: 4d43bb99-3a6c-58ea-8a24-8ee2c170ef00
DOI: 10.1101/2020.03.28.012732

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