Article
Spatial concordance of DNA methylation classification in diffuse glioma.
Neuro-oncology - 1 Dec 2021
Verburg Niels, Barthel Floris P, Anderson Kevin J, Johnson Kevin C, Koopman Thomas, Yaqub Maqsood M, Hoekstra Otto S, Lammertsma Adriaan A, Barkhof Frederik, Pouwels Petra J W, Reijneveld Jaap C, Rozemuller Annemieke J M, Beliën Jeroen A M, Boellaard Ronald, Taylor Michael D, Das Sunit, Costello Joseph F, Vandertop William Peter, Wesseling Pieter, de Witt Hamer Philip C, Verhaak Roel G W
Abstract excerpt
BACKGROUND: Intratumoral heterogeneity is a hallmark of diffuse gliomas. DNA methylation profiling is an emerging approach in the clinical classification of brain tumors. The goal of this study is to investigate the effects of intratumoral heterogeneity on classification confidence. METHODS: We used neuronavigation to acquire 133 image-guided and spatially separated stereotactic biopsy samples from 16 adult...
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