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Article

Diffuse Glioma Heterogeneity and Its Therapeutic Implications.

Cancer discovery - 1 Mar 2021

Nicholson James G, Fine Howard A

Abstract excerpt

Diffuse gliomas represent a heterogeneous group of universally lethal brain tumors characterized by minimally effective genotype-targeted therapies. Recent advances have revealed that a remarkable level of genetic, epigenetic, and environmental heterogeneity exists within each individual glioma. Together, these interconnected layers of intratumoral heterogeneity result in extreme phenotypic heterogeneity at the...

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Identifiers

PMID: 33558264
DOI: 10.1158/2159-8290.CD-20-1474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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