Article
Spatial heterogeneity in medulloblastoma.
Nature genetics - 1 May 2017
Morrissy A Sorana, Cavalli Florence M G, Remke Marc, Ramaswamy Vijay, Shih David J H, Holgado Borja L, Farooq Hamza, Donovan Laura K, Garzia Livia, Agnihotri Sameer, Kiehna Erin N, Mercier Eloi, Mayoh Chelsea, Papillon-Cavanagh Simon, Nikbakht Hamid, Gayden Tenzin, Torchia Jonathon, Picard Daniel, Merino Diana M, Vladoiu Maria, Luu Betty, Wu Xiaochong, Daniels Craig, Horswell Stuart, Thompson Yuan Yao, Hovestadt Volker, Northcott Paul A, Jones David T W, Peacock John, Wang Xin, Mack Stephen C, Reimand Jüri, Albrecht Steffen, Fontebasso Adam M, Thiessen Nina, Li Yisu, Schein Jacqueline E, Lee Darlene, Carlsen Rebecca, Mayo Michael, Tse Kane, Tam Angela, Dhalla Noreen, Ally Adrian, Chuah Eric, Cheng Young, Plettner Patrick, Li Haiyan I, Corbett Richard D, Wong Tina, Long William, Loukides James, Buczkowicz Pawel, Hawkins Cynthia E, Tabori Uri, Rood Brian R, Myseros John S, Packer Roger J, Korshunov Andrey, Lichter Peter, Kool Marcel, Pfister Stefan M, Schüller Ulrich, Dirks Peter, Huang Annie, Bouffet Eric, Rutka James T, Bader Gary D, Swanton Charles, Ma Yusanne, Moore Richard A, Mungall Andrew J, Majewski Jacek, Jones Steven J M, Das Sunit, Malkin David, Jabado Nada, Marra Marco A, Taylor Michael D
Abstract excerpt
Spatial heterogeneity of transcriptional and genetic markers between physically isolated biopsies of a single tumor poses major barriers to the identification of biomarkers and the development of targeted therapies that will be effective against the entire tumor. We analyzed the spatial heterogeneity of multiregional biopsies from 35 patients, using a combination of transcriptomic and genomic profiles....
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