Article

Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease

2019-09-12

Abstract excerpt

<h4>ABSTRACT</h4> Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on the bone marrow (BM) microenvironment, in particular on mesenchymal stromal cells (MSCs). MSCs from MM patients exhibit an abnormal transcriptional profile, suggesting that epigenetic alterations could be governing the tumor-promoting functions of MSCs and their prolonged osteoblast (OB) suppressi...

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Literature Corpus work: 4d4350d9-8481-5c73-ba99-510fe4c46d34
DOI: 10.1101/767897

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