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Article

Multiple myeloma mesenchymal stem cells: characterization, origin, and tumor-promoting effects.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2012

Reagan Michaela R, Ghobrial Irene M

Abstract excerpt

Hematologic malignancies rely heavily on support from host cells through a number of well-documented mechanisms. Host cells, specifically mesenchymal stem cells (MSC), support tumor cell growth, metastasis, survival, bone marrow colonization, and evasion of the immune system. In multiple myeloma, similar to solid tumors, supporting cells have typically been considered healthy host cells. However, recent evidence...

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Identifiers

PMID: 22065077
DOI: 10.1158/1078-0432.CCR-11-2212
PMCID: PMC3261316

Genes

MSC

Provenance

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