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Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease

18 Jan 2021

Abstract excerpt

Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epigenetic mechanisms governing their tumor-promoting functions and prolonged osteoblast suppression. Here, we identify widespread DNA methylation alterations of bone marrow-isolated MSCs from...

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PMID: 33462210
DOI: 10.1038/s41467-020-20715-x

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