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Article

A New Antifibrotic Target of Ac-SDKP: Inhibition of Myofibroblast Differentiation in Rat Lung with Silicosis

3 Jul 2012

Abstract excerpt

BACKGROUND: Myofibroblast differentiation, characterized by α-smooth muscle actin (α-SMA) expression, is a key process in organ fibrosis, and is induced by TGF-β. Here we examined whether an anti-fibrotic agent, N-acetyl-seryl-aspartyl-lysylproline (Ac-SDKP), can regulate induction of TGF-β signaling and myofibroblast differentiation as a potential key component of its anti-fibrotic mechanism in vivo and in...

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Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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PMID: 22802960
DOI: 10.1371/journal.pone.0040301

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