Article

Prediction and Classification of the Uptake and Disposition of Antidepressants and New CNS-Active Drugs in the Human Brain using the ANDROMEDA by Prosilico Software and Brainavailability-Matrix

2022-09-30

Abstract excerpt

<h4> A bstract </h4> <h4>Background</h4> Passive blood-brain barrier permeability (BBB P e ), fraction bound to brain tissue (f b,brain ) and efflux by transport proteins MDR-1 and BCRP are essential determinants for the brain uptake and disposition of drugs. <h4>Methods</h4> The main objective of the study was to use the software ANDROMEDA by Prosilico to predict passive BBB P e - and f b,brain -classes...

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Literature Corpus work: de440197-9e85-54fb-a056-ba648282c065
DOI: 10.1101/2022.09.28.509936

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