Article

Phosphorylation Mimicking Mutations Cause TDP-43 to Adopt Different Fibril Conformations

2026-05-17

Abstract excerpt

The Tar-DNA Binding Protein-43 C-terminal region, TDP43LC, has been previously shown to form amyloid-like fibrils with distinct folds in ALS and FTD. In both diseases, proteinaceous inclusions contain TDP43 C-terminal protein fragments as well as phosphorylated TDP43. Here, we use solution NMR to show that soluble phosphomimetic TDP43LC, P-TDP43LC, is structurally similar to wild-type TDP43LC. Disperse P-TDP43LC,...

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Literature Corpus work: 29be8a19-7942-5f60-8991-5c93a8c0fe4a
DOI: 10.64898/2026.05.14.725298

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