Article

Functional Activity and Binding Specificity of small Ankyrin Repeat Proteins called Ankyrons against SARS-CoV-2 variants.

2024-10-11

Abstract excerpt

Effective management of COVID-19 requires clinical tools to treat the disease in addition to preventive vaccines. Several recombinant mAbs and their cocktails have been developed to treat COVID-19 but these have limitations. Here, we evaluate small ankyrin repeat proteins called Ankyrons that were generated to bind with high affinity to the SARS-CoV-2 virus. Ankyrons are ankyrin repeat proteins comprised of repeti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4cdc7957-fad1-5f13-889d-096d5f7d9ade
DOI: 10.1101/2024.10.11.617752

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Functional Activity and Binding Specificity of small Ankyrin Repeat Proteins called Ankyrons against SARS-CoV-2 variants.DOI 10.1101/2024.10.11.617752Read

Designed Ankyrin Repeat Proteins: A New Class of Viral Entry InhibitorsSemantic proximity Read

Designed Ankyrin Repeat Proteins (DARPins): Binding Proteins for Research, Diagnostics, and TherapySemantic proximity Read

Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography.Semantic proximity Read

Aptamer‐based strategies against SARS‐CoV‐2 virusesSemantic proximity Read

A Decade of Clinical Experience with DARPins in Oncology and Virology: A Systematic ReviewSemantic proximity Read

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies.Semantic proximity Read

The DARPin Encyclopedia: from Basic Research towards TherapeuticsSemantic proximity Read

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodiesSemantic proximity Read

A Class of Shark‐Derived Single‐Domain Antibodies can Broadly Neutralize SARS‐Related Coronaviruses and the Structural Basis of Neutralization and Omicron EscapeSemantic proximity Read

Sybodies targeting the SARS-CoV-2 receptor-binding domainSemantic proximity Read

A pan-variant miniprotein inhibitor protects against SARS-CoV-2 variantsSemantic proximity Read

Rapid screening methods for universal binding peptide aptamers against SARS-CoV-2 variant spikes, including omicron variants, and their application to diagnostic and therapeutic agents.Semantic proximity Read