Article
A cocktail vaccine with monkeypox virus antigens confers protection without selecting mutations in potential immune evasion genes in the vaccinia WR strain challenge.
mBio - 11 Feb 2026
Sun Xintong, Zhang Luhua, Chen Guohua, Yang Fan, Ning Xiaoyu, Qiu Jinxin, Gao Yuxuan, Yang Jianshe, Zhang Wenhui, Zhang Zihui, Zhang Yueyue, Li Siyuan, Zeng Mingcong, Fu Baoquan, Li Yongfeng, Peng Chen, Li Weike
Abstract excerpt
Faced with the global monkeypox outbreak, current vaccine development predominantly focuses on the mRNA platform despite its limitations in stability and long-term efficacy. Here, we engineered a recombinant vesicular stomatitis virus (rVSV)-vectored cocktail vaccine encoding four conserved monkeypox virus (MPXV) antigens (A35R, A29L, M1R, and B6R; >94% clade homology), leveraging the thermostable properties of...
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