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Curcumin-cyclodextrin/cellulose nanocrystals improve the phenotype of Charcot-Marie-Tooth-1A transgenic rats through the reduction of oxidative stress.

Free radical biology & medicine - 1 Dec 2020

Caillaud Martial, Msheik Zeina, Ndong-Ntoutoume Gautier M-A, Vignaud Laetitia, Richard Laurence, Favreau Frédéric, Faye Pierre-Antoine, Sturtz Franck, Granet Robert, Vallat Jean-Michel, Sol Vincent, Desmoulière Alexis, Billet Fabrice

Abstract excerpt

The most prevalent form of Charcot-Marie-Tooth disease (CMT type 1A) is characterized by duplication of the PMP22 gene, peripheral dysmyelination and decreased nerve conduction velocities leading to muscle weakness. Recently, oxidative stress was reported as a feature in CMT1A patients. Curcumin exhibits antioxidant activities and has shown beneficial properties on peripheral nerves. However, curcumin presents...

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PMID: 32980538
DOI: 10.1016/j.freeradbiomed.2020.09.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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