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Article

Lineage-specific lncRNAs critically determine cross-species differences in tumors

2026-05-06

Abstract excerpt

Diverse mouse models have been generated to study human tumors. Although mouse and human tumors share similar differentially expressed genes and cancer hallmarks, many drugs that work in mice fail in humans. What makes mouse models poorly recapitulate human tumors remains unclear. We postulate that transcriptional regulation by lineage-specific long noncoding RNAs (LS lncRNAs) critically determines cross-species a...

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Literature Corpus work
4c8b36fb-9f04-51cb-9989-109f9d816d8f
DOI
10.64898/2026.05.01.722350
Open publication

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Lineage-specific lncRNAs critically determine cross-species differences in tumorsDOI 10.64898/2026.05.01.722350
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