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Article

Inhibitors of the Interactions between HIV‐1 IN and the Cofactor LEDGF/p75

19 Apr 2011

Abstract excerpt

The replication cycle of human immunodeficiency virus type 1 (HIV-1) is a complex multistep process that depends on both viral and host cell factors. The nuclear protein lens epithelium-derived growth factor (LEDGF/p75) is a multidomain protein, present in host cells, which plays an important role in the integration process. LEDGF/p75 not only binds HIV-1 integrase (IN) at its IN binding domain (IBD) but also...

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PMID: 21506277
DOI: 10.1002/cmdc.201100071

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Inhibitors of the Interactions between HIV‐1 IN and the Cofactor LEDGF/p75PMID 21506277Read ↗

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