Back to search

Article

Frailty and the Incidence of Major Ocular Diseases: A Prospective Cohort Study Integrating Proteomic Mediation Analysis

2026-08-18

Abstract excerpt

<title>Abstract</title> <p> Background The long-term association between frailty phenotype and major vision-threatening ocular diseases (age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma, and cataract), as well as the underlying molecular mechanisms, remain unclear. Methods Cox proportional hazards models were used to assess the association between frailty status (classified as non-fr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4c510337-0f0c-5922-b71d-c31f83540260
DOI
10.21203/rs.3.rs-10152825/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Frailty and the Incidence of Major Ocular Diseases: A Prospective Cohort Study Integrating Proteomic Mediation AnalysisDOI 10.21203/rs.3.rs-10152825/v1
Genetic liability to higher frailty index may increase the risk of ophthalmic disease.Semantic proximity
A Proteomic Profile of the Ocular Phenome: Systemic Signatures, Predictive Value, and Causal Insights Across 131 Ocular Diseases and TraitsSemantic proximity
Frailty and the Risk of Age-Related Macular Degeneration: A Prospective Cohort and Mendelian Randomization Study.Semantic proximity
Aging of the eye: Lessons from cataracts and age-related macular degenerationSemantic proximity
Incidence of and Risk Factors Associated With Age-Related Macular Degeneration: Four-Year Follow-up From the ALIENOR Study.Semantic proximity
Proteome-wide Mendelian randomization study implicates inflammaging biomarkers in retinal vasculature, cardiometabolic diseases and longevitySemantic proximity
Visual impairment, cognitive frailty, and psychosocial condition in elderly people: A mediation model and latent profile analysisSemantic proximity
Identification of cellular and molecular risk signatures for progression to late-stage age-related macular degeneration using the 9-step Minnesota Grading SystemSemantic proximity
Interacting and joint effects of frailty and inflammation on cardiovascular disease risk and the mediating role of inflammation in middle-aged and elderly populations.Semantic proximity
Understanding AMD by analogy: systematic review of lipid-related common pathogenic mechanisms in AMD, AD, AS and GN.Semantic proximity
Clonal Hematopoiesis of Indeterminate Potential and Risk of Major Age-Related Eye DiseasesSemantic proximity
Oxidative stress and its downstream signaling in aging eyesSemantic proximity
Select a neighboring publication to make it the new centre.