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Frailty and the Risk of Age-Related Macular Degeneration: A Prospective Cohort and Mendelian Randomization Study.

The journals of gerontology. Series A, Biological sciences and medical sciences - 10 Feb 2025

Zhu Xinyu, Huang Yikeng, Liang Li, Zhang Xinyu, Zhang Zixuan, Jiang Yujin, Wu Xiaoqian, Li Chenxin, Zheng Zhi, Bao Zhangli, Zou Wenjun, Zhao Shuzhi

Abstract excerpt

BACKGROUND: Both frailty and age-related macular degeneration (AMD) are related to aging and may share some common mechanisms. We aimed to examine the observational and causal association between frailty and the risk of AMD. METHODS: We included 320 810 participants free of AMD at baseline from the UK Biobank. Frailty phenotypes were defined according to 5 components: weight loss, exhaustion, slow gait speed, low...

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PMID: 39713956
DOI: 10.1093/gerona/glae300

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