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Article

Genetic liability to higher frailty index may increase the risk of ophthalmic disease.

International ophthalmology - 30 Sept 2024

Lin Jianwei, Lin Liling

Abstract excerpt

PURPOSE: Frailty and age-related eye diseases are common in older people; however, whether there is a causal link remains unknown. We aimed to explore the causal associations between the frailty index (FI) and ophthalmic traits and identify modifiable mediators. METHODS: Linkage disequilibrium score regression and two-sample Mendelian randomization were applied to identify genetic correlations and causal...

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PMID: 39347840
DOI: 10.1007/s10792-024-03319-y

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