Article
Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins.
Translational psychiatry - 7 Jan 2014
Hill W D, Davies G, van de Lagemaat L N, Christoforou A, Marioni R E, Fernandes C P D, Liewald D C, Croning M D R, Payton A, Craig L C A, Whalley L J, Horan M, Ollier W, Hansell N K, Wright M J, Martin N G, Montgomery G W, Steen V M, Le Hellard S, Espeseth T, Lundervold A J, Reinvang I, Starr J M, Pendleton N, Grant S G N, Bates T C, Deary I J
Abstract excerpt
Differences in general cognitive ability (intelligence) account for approximately half of the variation in any large battery of cognitive tests and are predictive of important life events including health. Genome-wide analyses of common single-nucleotide polymorphisms indicate that they jointly tag between a quarter and a half of the variance in intelligence. However, no single polymorphism has been reliably...
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